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Bioidentical Hormone Replacement Therapy Vs Synthetic

TRT Colombia

When considering hormone replacement therapy, it’s crucial to understand the distinctions between bioidentical and synthetic hormones. In this blog, we will take a close look at bioidentical hormone replacement therapy vs synthetic hormone therapy and see which one is the better option for you.

Bioidentical hormones are chemically identical to the hormones produced naturally by the human body, derived from natural sources like plants. In contrast, synthetic hormones are manufactured from synthetic compounds or animal sources and have different molecular structures compared to human hormones and both can significantly impact your overall health and well-being. Bioidentical hormones are often praised for their ability to closely mimic the body’s natural hormones, potentially offering a safer and more effective treatment with fewer side effects. On the other hand, synthetic hormones, while effective, might carry a higher risk of adverse effects due to their different chemical structures.

Recognizing these differences helps you choose the safest and most effective form of hormone replacement therapy tailored to your individual health needs and goals. This knowledge empowers you to make informed choices that can lead to better management of hormonal imbalances and improved quality of life.

What is Bioidentical Hormone Replacement Therapy?

Bioidentical Hormone Replacement Therapy (BHRT) uses hormones that are chemically identical to those the human body produces naturally. These hormones are derived from natural sources, such as plant estrogens, and are tailored to match each individual’s hormonal needs. Understanding what is bioidentical hormone replacement therapy will help you to understand how to restore balance by replenishing deficient hormones, and addressing symptoms associated with menopause, andropause, and other hormone imbalances.

In BHRT, customized formulations are often used, including bioidentical estrogen and bioidentical progesterone. Saliva testing may be employed to assess hormone levels and create individualized treatment plans. This type of hormone therapy is popular for its perceived safety and effectiveness in managing menopausal symptoms, such as hot flashes, night sweats, and mood swings.

What is Synthetic Hormone Replacement Therapy?

What is Synthetic Hormone Replacement Therapy?

Synthetic Hormone Replacement Therapy (SHRT) involves the use of hormones that are not identical in structure to those produced by the human body. These hormones are typically made from synthetic compounds or animal sources, such as conjugated equine estrogens derived from pregnant mares. Understanding what is a synthetic hormone is crucial, as these hormones are designed to mimic natural hormones but have different molecular structures. SHRT is commonly used to treat hormonal imbalances but may carry different risks and benefits compared to BHRT.

Synthetic hormone therapy includes synthetic testosterone and synthetic progesterone compounds, which are designed to mimic the effects of natural hormones. However, the differences in chemical structures can lead to variations in how these hormones are metabolized and their potential side effects. The U.S. Food and Drug Administration (FDA) regulates many forms of synthetic hormone therapy, ensuring standardized dosages and quality control.

What’s the Difference between Synthetic and Bioidentical?

The primary difference between synthetic and bioidentical hormones lies in their molecular structure. Bioidentical hormones are an exact match to human hormones, allowing them to mimic the body’s natural hormone functions more closely. Synthetic hormones, however, have different structures, which may affect how they interact with the body and how they are metabolized.

Chemical Structures and Sources:

  • Bioidentical Hormones: Derived from natural sources like plants and tailored to match human hormones.
  • Synthetic Hormones: Made from synthetic compounds or animal sources with different molecular structures.

Forms of Hormone Replacement:

  • Bioidentical: Often custom-compounded to meet individual needs, including hormone pellets, creams, and gels.
  • Synthetic: Available in standardized forms, such as pills, patches, and injections, often regulated by the FDA.

The Benefits

Bioidentical Hormone Replacement Therapy

The benefits of bioidentical hormone replacement therapy are often highlighted due to its natural approach and individualized treatment plans. Some key benefits include:

  • Reduced Risk of Side Effects: Because bioidentical hormones match the body’s natural hormones, they may cause fewer side effects compared to synthetic hormones. This includes a lower risk of weight gain and other common side effects.
  • Personalized Treatment: BHRT can be customized to address the specific hormonal needs of each patient, potentially leading to more effective symptom relief. This includes managing hormonal imbalances that cause menopausal symptoms and hormone deficiencies.
  • Improved Symptom Management: BHRT is effective in managing symptoms of menopause, such as hot flashes, night sweats, mood swings, and other forms of hormone imbalance. Custom-compounded bioidentical hormone therapy can also help with testosterone replacement therapies for men.

Synthetic Hormone Replacement Therapy

Synthetic Hormone Replacement Therapy

While synthetic hormone replacement therapy is effective in treating hormonal imbalances, it comes with its own set of benefits and risks. Some advantages include:

  • Established Protocols: SHRT has been widely studied and used for many years, providing a wealth of data on its efficacy and safety. This traditional hormone replacement therapy is well-documented in medical history.
  • Availability: Synthetic hormones are often more readily available and may be covered by insurance more frequently than bioidentical hormones. FDA-approved hormone therapies offer standardized dosages, which can simplify treatment plans for some patients.
  • Standardized Dosages: SHRT offers standardized dosages, ensuring consistent and controlled hormone levels, which can be crucial for maintaining hormone balance and addressing health risks associated with hormone deficiencies.


Choosing between bioidentical and synthetic hormone replacement therapy depends on various factors, including individual health needs, risks, and preferences. While BHRT offers a more natural and personalized approach, SHRT has the advantage of established protocols and accessibility. Consulting with a healthcare provider is essential to determine the most suitable therapy for your specific situation.

At TRT Colombia, we specialize in connecting clients to our network of pre-qualified doctor allies who offer comprehensive hormone therapy solutions. Whether you’re exploring Bioidentical Hormone Replacement Therapy (BHRT) for women or seeking effective HRT for weight loss, our expert partners provide tailored treatments designed to meet your unique health needs. By facilitating access to trusted medical professionals, we ensure you receive the highest quality care. Discover a path to better health and well-being with TRT Colombia.


How long can you take bioidentical hormones?

The duration of BHRT can vary depending on individual health needs and goals. Some people may take bioidentical hormones for a few years, while others may continue therapy for a longer period. It is essential to have regular check-ups with a healthcare provider to monitor hormone levels and adjust treatment as needed. The risk of breast cancer and other potential risks should be evaluated continuously to ensure safe and effective therapy.

When is it too late to start bioidentical hormones?

There is no definitive age limit for starting BHRT, but it is generally more effective when begun earlier in the process of hormonal decline. However, even individuals in their 60s or older may benefit from BHRT, depending on their health status and specific symptoms. A healthcare provider can help determine the best time to start treatment, considering factors such as cardiovascular disease and other existing health conditions.

Who needs bioidentical hormones?

Bioidentical hormones may be beneficial for individuals experiencing symptoms of hormonal imbalance, such as those related to menopause, andropause, or other endocrine disorders. Common candidates include women undergoing menopause, men with low testosterone levels, and individuals with thyroid disorders or adrenal insufficiency. A thorough medical evaluation is necessary to determine if BHRT is appropriate, including assessing salivary hormone levels and overall medical history. This treatment option can significantly improve quality of life by addressing hormone production and balance issues effectively.

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